- Co-processing of API with inorganic materials
- Spherical crystallization scale-up / industrialization
- Ab-initio solubility prediction enhanced by machine learning
- Team-oriented and decision-making personality
- Problem solving-oriented work habits
- Good knowledge of MS-Office (Word, Excel, PowerPoint) & Google equivalents (gSheets, gDocs, gSlides)
- Proficient in English, German is a plus
- Experience working in a lab-environment.
- Knowledge in process engineering, powder processing, as well as powder characterization techniques
- Knowledge in process engineering, crystallization and granulation techniques, as well as formation of emulsions and their stabilization
- Good knowledge of python programming
- Basic knowledge of pandas, scikit-learn, XGBoost and Random forest regression models and hyperparameter tuning
- Basic knowledge of Jupyter Notebooks
- Ideally experience with Linux and Windows OS
- Ideally first experience with solid state characterization techniques: PXRD, DSC, TGA
- A Current CV and a Motivation Letter
- A certificate of enrollment (if you are currently studying). If you want to use this opportunity to do a Master's or Diploma thesis, please highlight this in your application
- Due to regulations, you must provide a certificate issued by your university stating that an Internship is mandatory for your studies
- for non-EU/EFTA candidates: this is required for each and every duration of the internship
- for EU/EFTA candidates: this is only required if you would like to stay for more than 6 month -
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Student Internships in Solid State Science for students enrolled in chemistry, chemical or process engineering, pharmacy, pharmaceutical sciences, pharmaceutical technology, or physics - Basel, Schweiz - Roche
Beschreibung
The Position
Student Internships in Solid State Science for students enrolled in chemistry, chemical or process engineering, pharmacy, pharmaceutical sciences, pharmaceutical technology, or physics
As part of the global technical development organization, the Particle Design group is the center of excellence for the design of drug substance particles with tailor-made solid-state properties to facilitate downstream processing to the drug product. This includes the development and optimization of the processes on laboratory scale, as well as scale-up of the corresponding manufacturing processes in close collaboration with the production sites. Our responsibilities also include the evaluation and implementation of new strategies to obtain particles with the desired properties.
As an Intern in the particle design group you will be working on one of the following project-areas:
The goal of the project is to refine the preparation process and assess the benefits of co-processing APIs with inorganic compounds, using either mechanical dry-surface coating or adsorption onto mesoporous carriers, aiming at an improvement of their processability in the desired pharmaceutical formulation principle.
Further development of the spherical crystallization methodology with focus on application at scale in an industrial setting (focus on dosing/mixing, filtration and drying)
Improvement of the already established workflow for the solubility computation by a machine-learning module. This includes an experimental part (70% laboratory work including sample preparation, solubility measurements and solid residue analysis) as well as a computational part: The remaining 30% will be dedicated to data preparation, model training and evaluation of different machine learning models.
Who you are
You are an enrolled student in the subject of chemistry, chemical or process engineering, pharmacy, pharmaceutical sciences, pharmaceutical technology, physics or a related field (preferably with a bachelor's degree) and have an interest and experience in crystallization and solid-state characterization. Furthermore, you are interested in using and sharing your knowledge as part of a 6-12 months internship in a modern working environment.
Your further profile for one of the positions:
General:
For project area A: Mechanical dry-surface coating / adsorption onto mesoporous carriers
For project area B: Spherical crystallization scale-up / industrialization
For project area C: Ab-initio solubility prediction enhanced by machine learning
These internship opportunities are three of a number of positions we offer in the department per semester. The interviews will take place on an interview day with all considered candidates and the whole department.
Your complete application includes the following documents
Application Process
The Internship will start in 2024 for 6-12 months , please indicate your preferred start date and duration in your application.
More information about the Roche Internship program in Synthetic Molecules (RiSM) and other opportunities within this program you can findhere.
Roche embraces diversity and equal opportunity in a serious way. We are committed to building a team that represents a variety of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.
Are you ready to apply? We are looking for someone who thinks beyond the job offered - someone who knows that this position can be a rare springboard to many other opportunities