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Bioassay Expert - Bern, Schweiz - Adecco

Adecco

Geprüftes Unternehmen

Bern, Schweiz

vor 2 Wochen

Geschrieben von:

Lena Schneider

beBee Recruiter

Beschreibung

For our client a leading global biotechnology company we are looking for a motivated

Bioassay Expert (M/F/d) 100%:

Your challenges

Responsible for providing critical cellbased assay expertise to complement the existing inhouse product characterization team and delivering on cellbased functional assays as per project requirements using appropriate state of the art technology platforms
Responsible for defining phaseappropriate bioassay strategies for product development. In addition, enabling characterization of products and link to the targeted mechanism of action (MoA) using design of experiment (DOE) and analytical QbD
Responsible for executing, developing, optimizing and qualifying functional assays (cellular and molecularbased assays as appropriate) to mimic in vivo product efficacy and/or safety
Actively contribute to new methodologies and next generation technologies by keeping abreast of next generation platforms, identifying, evaluating, and implementing appropriate innovative approaches with a focus on potency assays
Responsible for supervising and coaching junior scientist in performing and developing cellbased methods
Act as BAS Subject Matter Expert (SME) relating to cellular and biologicalrelated assays, provide scientific input to multiple projects and technical teams
Ensure successful transfer of assays and knowledge to contract labs/CROs including troubleshooting issues relating to challenges in setting up the assays at the CRO labs
Author lab procedures, protocols, reports and SOPs for internal and/or external partners. Present at internal and external seminars and conferences
Collaborate with Group members and crossfunctional teams to support product characterization, process development, and other studies. Ensure close collaboration with other local and global CSL functions across the R & D network

Your skills

D. in Cell Biology, Biochemistry, Biological Sciences or related fields with +3 years of biopharmaceutical industry experience in the field of cellular and molecular assay development for product development

Excellent understanding of biological and cellular mechanism of actions (MoA) of different biomolecules (antibodies, therapeutic proteins) for the development of fitfor purpose assay to determine product safety and efficacy
Handson experience in a wide range of biological and immunological techniques (eg. FACS, chemiluminescence, fluorescence, FRET, LANCE, FP) as well as affinitybased techniques (SPR, BLI)
A solid understanding of current statistical approaches and data analysis packages to evaluating potency results (e.g. GraphPad Prism, SoftMax Pro, JMP, Matlab, PLA)
Handson experience in good cell culture practices such as excellent aseptic techniques, isolating, culturing and troubleshooting as required. Experience working with BSL2 level biological agents
Good understanding of scientific process, including hypothesis development and experimental design (DoE) with an ability to capture, design and record complex scientific data accurately and reliably
Proficient English verbal and written communication skills with ability to work independently as well as in a team environment

Your horizons