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Postdoc position: quantitative biology of non-growing bacteria - Basel, Schweiz - The Biozentrum, University of Basel
Beschreibung
Your positionThe topic of this project concerns Escherichia coli during stationary phase, as a case study of non-growing bacteria.
Although bacteria in the wild likely spend the majority of their time in non-growing states, relatively little is known about cell physiology and gene expression in such states, especially at the single-cell level.
Our lab uses novel quantitative approaches, such as the one we recently developed to quantitatively track growth and gene expression with single-cell resolution in bacteria exposed to controlled environmental changes [1, 2].
We are interested in both physiological and evolutionary aspects of stationary phase:What are the different physiological states that can be attained during stationary phase? What is the extent and dynamics of cell heterogeneity during stationary, and how does this heterogeneity affect survival, stress-resistance, and the ability of cells to regrow when exposed to new nutrients? Are there evolutionary trade-off(s) between growth-related traits and starvation-related traits? To answer such questions, the candidate is expected to combine experimental techniques from molecular biology, genetics, video-microscopy, microfluidics and microfabrication, with cutting-edge data analysis and modelling techniques, which may be undertaken in collaboration with theoretical researchers in the lab.
The project will be tailored to the interests and skills of the successful candidate, and will take advantage of several recent results already obtained in our group.
Your profileApplicants should have completed a PhD in a relevant field such as biophysics, quantitative biology, microbiology, or evolution. Previous experience with microscopy and microfluidics will be valued. The candidate should have demonstrated experience in programming for data analysis, and/or in mathematical modelling.
