Contractor for Adme - Basel, Schweiz - Work Selection

Beschreibung

Beschreibung:

For our international medical partner, F. Hoffmann-La Roche Ltd.

in Basel, we are looking for a qualified and motivated
Contractor for ADME - enzymology and DDI for a temporary contract of 12 months.

Tasks:

• Conduct the laboratorybased assays in in vitro enzymology/DDI and allied experimental areas of small molecule drug metabolism as e.g. incubation of test substances using hepatocytes, human liver microsomes, recombinant enzymes
• Analyzing incubation samples via LC-MS/MS and radioHPLC, including bioanalytical method development and/or validation.
• Plan, monitor, communicate and report enzymology/DDI studies both in a drug discovery and drug development setting reporting to the respective laboratory staff and supervisors
• Perform rigorous verification and develop best practices to improve the regular enzymology/DDI assays where current approaches are inadequate
• Some time may be spent in supporting the development of new enzyme phenotyping methodologies and approaches with the help of automation

Must Haves:

• You gained good knowledge of metabolic enzyme biochemistry (e.g. CYP450, UGT), handson/experimental enzyme kinetics assessment and the respective experimental designs
• Experience in bioanalytical method development/validation for radioHPLC (e.g. Thermo) and LC-MS/MS (e.g. Sciex). This includes troubleshooting and data analysis Analyst software)
• You have a strong interest in translational approaches leveraging in vitro data and clinical data
• Fluent English

Nice to have:

• Previous experience working in the pharmaceutical industry, biotech or CRO
• German skills
• Working knowledge of regulatory expectations for enzymology studies (e.g. chemical inhibition, recombinant enzyme and correlation studies) is an advantage

Wir wertschätzen Vielfalt und begrüssen daher alle Bewerbungen - unabhängig von Geschlecht, sozialer Herkunft, Religion, Alter und Identität. Zur leichteren Lesbarkeit und besseren Verständlichkeit verwenden wir nur eine Gender-Form. Selbstverständlich sind im jeweiligen Kontext alle Genderformen gleichermassen gemeint.